These Global Polio Eradication Initiative (GPEI) SOPs establish response standards and timelines for actions to stop transmission when WPV spreads to a non-endemic country, or when VDPV events and/or outbreaks of any type are detected in any context, whether a new emergence or previously undetected circulating vaccine-derived poliovirus (cVDPV). This document updates the most recent version of the polio outbreak SOPs published November 2017. This version 3.0 of the SOPs incorporates lessons learned from previous outbreak response efforts since the tOPV/bOPV switch in April and May of 2016. The SOPs summarize the roles and responsibilities of countries and GPEI partners during a polio outbreak or event. Since WPV2 is now considered an eradicated pathogen, specific measures are outlined for responding to type 2 events and outbreaks, including how to request and account for monovalent oral type 2 polio vaccine (mOPV2) from the global emergency vaccine stockpile. Search Terms: SOP, Guide, response, manual, guide, guideline, global, management, World Health Organization (WHO), Strategic Advisory Group of Experts (SAGE) on immunization, GPEI, standard operating procedures